A collaborative research study by researchers, including Associate Professor Takayuki Nonoyama (Faculty of Advanced Life Science, Hokkaido University) and Professor Norimasa Iwasaki (Faculty of Medicine, Hokkaido University) of the Soft Materials Creation Platform team, has been published in Biomaterials Advances.
- Yuki Ogawa, Kosuke Arita, Takayuki Nonoyama, Kano Sato, Ryota Watanabe, Liyile Chen, Tsutomu Endo, Taiki Tokuhiro, Hend Alhasan, Daisuke Takahashi.Norimasa Iwasaki, M. Alaa Terkawi. Transcriptomic profiling of osteoblasts on hydroxyapatite-coated-metal-surface reveals enhanced osteogenic and angiogenic processes relevant to accelerated bone healing. Biomaterials Advances, 182 (May 2026): 214672
DOI: https://doi.org/10.1016/j.bioadv.2025.214672
Abstract
Hydroxyapatite (HA) coating on orthopedic implants is known to promote osteogenesis and improve bone-implant integration, yet its molecular basis remains to be investigated. Here, transcriptomic profiling of osteoblasts on nano-HA (nHA)-coated surfaces revealed increased expression of key osteogenic and angiogenic molecules. These findings provide the first molecular mechanistic insight into how nHA coatings accelerate osteogenesis and bone healing.